Curated PI3K (Phosphoinositide 3-kinase) Network

This network is a curated version of a network created by harvesting citing and cited articles around Whitman et al. (1988) Nature, 332(6165):644–646. For further details refer to https://databank.illinois.edu/datasets/IDB-4897629. Curation was performed by removing nodes (articles identified by Dimensions publication ids) whose year or DOI record was missing from the Dimensions database and retaining the largest connected component of the resulting network. This curated network represents the largest connected component. Integer ids were generated by the authors to replace the Dimensions ids. Access to the raw data requires a license from Digital Science.

The original pi3k network contains 17,970,340 nodes of which only 17,508,111 (97.42%) them have both year and DOI information. In this curated version, 127,255,020 edges were reduced to 125,118,817 edges (98.32%). The edges are represented with two columns in the file where the "source_iid" column represents the citing node and "target_iid" column represents the cited node. Restricting the original pi3k network to only those nodes with both year and DOI information results in a graph that has 21,469 connected components where the largest connected component has 17,486,619 nodes (97.31%) . Thus, this network represents 97.31% of the nodes and 98.32% of the edges in the original network. The authors thank Digital Science for supporting this project through access to the Dimensions database.