The compiled datasets include detailed costs for switchgrass production, categorized into establishment, maintenance, and harvesting expenses, along with revenue calculations. Costs were gathered from multiple sources and adjusted for inflation, focusing on farm-gate profitability, excluding fixed costs and transportation. All financial data is provided per hectare. The dataset was used to evaluate the economic performance of forage- and bioenergy-type switchgrass cultivars and their response to nitrogen fertilization across diverse marginal environments in the U.S. Midwest. Data Envelopment Analysis (DEA) and cost-benefit analysis were employed to assess the efficiency and profitability of 23 different cultivar and fertilization rate combinations over five years.